Methadone is contraindicated hinein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient rein methadone hydrochloride tablets.

Take methadone hydrochloride tablets exactly as prescribed. Follow your doctor's directions exactly. Your doctor may change your dose based on your reactions to the medicine.

Don’t put this medication hinein your car’s glove compartment or leave it rein the car. Be sure to avoid doing this when the weather is very hot or very cold.

Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result rein toxic effects.

Acute Pain – Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, in doses that would otherwise be indicated for non-methadone-treated patients with similar painful conditions.

Methadone treatment for analgesic therapy in patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone has been considered to outweigh the risk of QT prolongation that has been reported with high doses of methadone.

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Patients and their caregivers should Beryllium advised to discard unused methadone rein such a way that individuals other than the patient for whom it was originally prescribed will not come rein contact with the drug.

Do not change your dose unless your doctor tells you to change it. Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possibly death.

Methadone treatment for analgesic therapy hinein patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone is considered and outweighs the risks.

Desipramine – Blood levels of desipramine have increased with concurrent methadone administration.

However, the risk is highest when you first Ausgangspunkt taking the drug and after a dosage increase. Your risk may also be higher if you’Response older or already have breathing or lung problems.