Mutagenesis – There are several published reports on the potential genetic toxicity of methadone. Methadone tested negative in tests for chromosome breakage and disjunction and sex-linked recessive lethal gene mutations rein germ cells of Drosophila using feeding and injection procedures.

As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. The following dosing recommendations should only be considered as suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.

If you take too much methadone hydrochloride tablets or overdose, call 911 or your local emergency number right away.

Methadone should Beryllium used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

For patients judged to Beryllium at risk, careful monitoring of cardiovascular Verfassung, including QT prolongation and dysrhythmias and those described previously should be performed.

Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prestigevoll of which involves the central nervous Organisation and organs composed of smooth muscle.

Fertility – Reproductive function hinein human males may be decreased by methadone treatment. Reductions in ejaculate volume and seminal vesicle and prostate secretions have been reported hinein methadone-treated individuals. Hinein addition, reductions in serum testosterone levels and sperm motility, and abnormalities hinein sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can lebensalter reproductive function.

Methadone is a mu-agonist opioid with an abuse liability similar to that of morphine and is a Schedule II controlled substance. Methadone, like morphine and other opioids used for analgesia, has the potential for being abused and is subject to criminal diversion.

Methadone should Beryllium used with caution rein elderly and debilitated patients; patients Weltgesundheitsorganisation are known to be sensitive to central nervous Struktur depressants, such as those with cardiovascular, pulmonary, renal, or hepatic disease; and in patients with comorbid conditions or concomitant medications which may predispose to dysrhythmia.

As with all opioids, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression rein the newborn, especially if higher doses are used. Methadone is not recommended for obstetric analgesia because its long duration of action increases the probability of respiratory depression hinein the newborn.

Methadone products when used for the treatment of opioid addiction rein detoxification or maintenance programs, shall Beryllium dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority.

For people with seizures: This drug may cause more seizures hinein people with epilepsy. If your seizure control gets worse while taking this drug, call your doctor.

Patients seeking to discontinue methadone maintenance treatment of opioid dependence should be apprised of the high risk of relapse to illicit drug Methadontabletten ohne Rezept online use associated with discontinuation of methadone maintenance treatment.

Methadone should Beryllium administered with particular caution to patients already at risk for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia). Careful monitoring is recommended when using methadone rein patients with a history of cardiac conduction abnormalities, those taking medications affecting cardiac conduction, and hinein other cases where history or physical exam suggest an increased risk of dysrhythmia. QT prolongation has also been reported hinein patients with no prior cardiac history World health organization have received high doses of methadone.