Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in methadone hydrochloride tablets.

Methadone produces a significant regression of sex accessory organs and testes of male mice and rats. Additional data have been published indicating that methadone treatment of male rats (once a day for three consecutive days) increased embryolethality and neonatal mortality. Examination of uterine contents of methadone-naive female mice bred to methadone-treated mice indicated that methadone treatment produced an increase rein the Satz of preimplantation deaths in all post-meiotic states.

Under the requirements of this REMS program, the drug manufacturer must develop educational programs regarding the safe and effective use of opioids for your doctor

Selection of patients for treatment with methadone should Beryllium governed by the same principles that apply to the use of other opioids (see INDICATIONS AND USAGE).

Switching a patient from another chronically administered opioid to methadone requires caution due to the uncertainty of dose conversion ratios and incomplete cross-tolerance. Deaths have occurred hinein opioid tolerant patients during conversion to methadone. Conversion ratios in many commonly used equianalgesic dosing tables do not apply rein the Rahmen of repeated methadone dosing.

gemischt, um euphorisierende Wirkungen zu vermeiden → verhindert die Gefahr des schädlichen Opioidkonsums, sowie es injiziert statt oral eingenommen wird

Fertility – Reproductive function hinein human males may be decreased by methadone treatment. Reductions rein ejaculate volume and seminal vesicle and prostate secretions have been reported rein methadone-treated individuals. In addition, reductions in serum testosterone levels and sperm motility, and abnormalities in sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can alter reproductive function.

Based on an average milk consumption of 150 mL/kg/day, an infant would consume approximately 17.4 mcg/kg/day which is approximately 2 to 3% of the oral maternal dose. Methadone has been detected in very low plasma concentrations rein some infants whose mothers were taking methadone. Women on high-dose methadone maintenance, Weltgesundheitsorganisation are already breast-feeding, should Beryllium counseled to wean breast-feeding gradually rein order to prevent neonatal abstinence syndrome.

Do not drive, operate heavy machinery, or do other possible dangerous activities until you know how methadone hydrochloride tablets affect you. Methadone hydrochloride tablets can make you sleepy. Ask your doctor when it is okay to do these activities.

Schulnote Methadontabletten 10 mg online – Equianalgesic methadone dosing varies not only between patients, but also within the same patient, depending on baseline morphine (or other opioid) dose. Table 1 has been included rein order to illustrate this concept and to provide a safe starting point for opioid conversion. Methadone dosing should not be based solely on these tables. Methadone conversion and dose titration methods should always Beryllium individualized to account for the patient's prior opioid exposure, general medical condition, concomitant medication, and anticipated breakthrough medication use.

Patients should Beryllium instructed to keep methadone hinein a secure place out of the reach of children and other household members. Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death.

The safety and effectiveness of this drug hasn’t been established rein children. It shouldn’t be used in children younger than 18 years.

The relative potency estimate used to calculate an equianalgesic starting methadone dose, rein particular, whether it is intended for use in acute or chronic methadone dosing;

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